Findings

This image shows a portion of the small intestine that is markedly thickened due to inflammation, edema and fibrosis. Note that foci of inflammation is distributed in all the layers (transmural in distribution). A small fissure is beginning to extend from the mucosa to the submucosa. Mural thickening is most marked in the submucosa where loose connective tissue is abundant.

Impression

Small intestine, Crohn's disease

Preparation

Fixed, H & E stain

View

Light microscopy

Specimen

Small intestine

Image Credit

Katsumi M. Miyai, M.D., Ph.D
Department of Pathology
School of Medicine
University of California, San Diego