Findings

Note a focus of granulomatous inflammation with a multinucleated giant cell.

Impression

Granulomatous inflammation consistent with Crohn's disease.

Pathology Pointer

Microscopically, Crohn's disease is characterized by: 1. Transmural inflammation consisting pre- dominantly of lymphocytes and plasma cells. 2. Granulomas, which are occasionally present, although they are not a specific finding. Gran- ulomas are often absent. 3. Occasional fissure formation. 4. Mucosal injury.

Preparation

Fixed, H & E stain

View

Light microscopy

Specimen

Small intestine

Image Credit

Katsumi M. Miyai, M.D., Ph.D
Department of Pathology
School of Medicine
University of California, San Diego