Findings

At high power, the crimson-staining Paneth cells can be seen at the base of the intestinal glands (crypts of Lieberkuhn). Subjacent to the muscularis mucosae, portions of Brunner's glands can be seen in the submucosa.

Comment

Paneth cells are a histological marker of the small intestine. The secretory product of Paneth cells is an antibacterial enzyme called lysozyme that degrades bacterial cell walls.

Preparation

Paraffin section, hematoxylin and eosin

View

High-power light microscopy

Specimen

Duodenum, Small intestine

Image Credit

Katsumi M. Miyai, M.D., Ph.D
Department of Pathology
School of Medicine
University of California, San Diego