Findings

In this image, a secondary ossification center in the epiphysis is seen above the growth plate. Note blood vessels, perivascular osteoprogenitor cells, hypertrophied chondrocytes and ossifying matrix in the secondary ossification center.

Comment

While the epiphysis and metaphysis ossify, hyaline cartilage remains in the growth plate until growth of long bones is completed.

Preparation

Paraffin section, hematoxylin and eosin

View

Medium-power light microscopy

Specimen

Secondary ossification center

Image Credit

Katsumi M. Miyai, M.D., Ph.D
Department of Pathology
School of Medicine
University of California, San Diego