Findings

Lateral view of lower femur, knee, tibia and fibula. Note an ill-defined bony destruction in the knee region with increased radiodensity (due to ossification).

Impression

Malignant neoplasm of the bone, probably osteosarcoma.

Clinical Pathologic Correlation
Osteosarcoma is a malignant mesenchymal neoplasm in which the neoplastic cells produce osteoid. Excluding multiple myeloma (a tumor of B lymphocyte origin), osteosarcoma in the most common primary malignant tumor of the bone.

View

Radiograph

Specimen

Lower extremity around the knee

Image Credit

Parviz Haghighi, M.D.
Department of Pathology
School of Medicine
University of California, San Diego