Findings

The slide shows neoplastic plasma cells with eccentric round to oval purple nuclei and basophilic cytoplasms. Some binucleated forms are present.

Impression

Multiple myeloma

Clinical Pathologic Correlation
Proliferation of a single clone of neoplastic plasma cells results in the production of a single homogeneous immunoglobulin or its fragments. In 15-20% of cases, plasma cells produce only or light chain, which, because of their low molecular weight, are excreted in the urine as Bence-Jones protein.

Preparation

Smear, Wright stain

View

Light micrograph

Specimen

Tumor tissue in the bone

Image Credit

Elizabeth Broome, M.D.
Department of Pathology
School of Medicine
University of California, San Diego