Findings

In the low power image (left), bone resorption is markedly increased secondary to hyperparathyroidism. Note the extremely irregular, jagged borders of the individual bony trabeculae and so-called "tunneling resorption". Many osteoclasts are seen in resorption bays (Howship's lacunae). In addition, fibrous replacement of the marrow space bordering the trabeculae is present. Higher magnification (right) shows many osteoclasts bordering scalloped bony trabeculae in the process of resorption. The fibrous tissue deposition can be seen in the marrow space.

Impression

Hyperparathyroidism (increased bone resorption)

Preparation

Fixed and decalcified, H & E stain

View

Light micrograph

Specimen

Bone

Image Credit

Parviz Haghighi, M.D.
Department of Pathology
School of Medicine
University of California, San Diego