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Note the spongiosis in the epidermis, i.e. widening of the intercellular space due to accumulation of inflammatory edema. Accumulation of the edema fluid has also formed blisters. Inflammatory cells seen here are mainly lymphocytes.
Acute allergic contact dermatitis.
Spongiosis, formed by leakage of fluids from dermal capillaries into the epidermis, is a key feature of contact dermatitis.
Fixed, H & E stain
Katsumi M. Miyai, M.D., Ph.D
Department of Pathology
School of Medicine
University of California, San Diego
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