Findings

This tumor is composed of numerous multinucleated giant cells mixed with round to spindle-shaped neoplastic cells with similar nuclei. Note the absence of fibrous stroma between the cells.

Impression

Giant cell tumor

Clinical Pathologic Correlation
The biologic behavior of this tumor is somewhat unpredictable. Although it appears benign histologically, it tends to recur after surgical resection. Malignant transformation is rare but may occur.

Pathology Pointer

Although multinucleated giant cells are prominent in this tumor, they are thought to result from the fusion of reactive monocytes. The neoplastic cells are believed to be the round to spindle-shaped cells.

Preparation

Fixed, H & E stain

View

Light micrograph

Specimen

Tumor of the bone

Image Credit

Parviz Haghighi, M.D.
Department of Pathology
School of Medicine
University of California, San Diego