Findings

During the secretory phase of the endometrium, uterine glands are coiled and distended with secretory products in their lumina. The surrounding connective tissue becomes highly vascular and edematous.

Comment

The secretory phase of the endometrium is characterized by the presence of coiled and distended uterine glands. This phase takes place after ovulation and the formation of a corpus luteum. As the corpus luteum secretes increased amounts of progesterone, the uterine glands become wider, highly tortuous and secrete increased amount of glycogen-rich products that accumulate in their lumina. The endometrium thickens and the connective tissue becomes vascular and edematous. These changes are restricted to the functional layer and prepare the endometrium for possible implantation of the blastocyst.

Preparation

Paraffin section, hematoxylin and eosin

View

Medium-power light microscopy

Specimen

Uterus

Image Credit

Katsumi M. Miyai, M.D., Ph.D
Department of Pathology
School of Medicine
University of California, San Diego