Findings

This image shows the key histologic and diagnostic features of cirrhosis, namely, fibrous septa, regenerative nodules, and extensive parenchymal involvement.

Impression

Hepatic cirrhosis

Clinical Pathologic Correlation
Clinical studies alone do not establish the diagnosis of cirrhosis. Histopathologic confirmation is required for a definitive diagnosis.

Pathology Pointer

Nodules shown in this image vary a great deal in size and some of the larger ones contain intact lobules. This type of cirrhosis, called macronodular cirrhosis, typically results from chronic hepatitis in which the distribution and severity of tissue injury are not uniform.

Preparation

Fixed, H & E stain

View

Light micrograph

Specimen

Liver

Image Credit

Katsumi M. Miyai, M.D., Ph.D
Department of Pathology
School of Medicine
University of California, San Diego